Noureddine Melikechi is professor of physics and dean of the Kennedy College of Science at the University of Massachusetts in the United States. Professor Melikechi has developed a new laser analysis technique called Atomic Emission Spectrometry which can detect cancer antigen 125 (CA 125), one of the biomarkers of ovarian cancer. This spectroscopic technique is also used to study the composition of the planet’s surface. Professor Melikechi was also a member of the NASA scientific team which analyzes data sent by the “ChemCam” instrument on board of the Curiosity rover. It is in recognition of his scientific contribution that in 2011, the governor of Delaware named Professor Melikechi “Mars Ambassador.”
This is an interdisciplinary book that presents the applications of novel laser spectroscopy and imaging techniques for the detection of cancers recently developed by some of the world’s most renown researchers. The book consists of three parts and a total of 16 chapters. Each chapter is written by leading experts who are actively seeking to develop novel spectroscopic and analytical methods for cancer detection and diagnosis.
In Part I, the authors present fundamentals on optics, atoms and molecules, biophysics, cancer and machine learning. These chapters are intended for those who are not experts in the field but wish to learn about fundamentals’ aspects of some of the key topics that are addressed in this book. Particular attention has been given to providing key references for those who wish to go further into the fundamental aspects of atoms and molecules, light-matter interaction, optical instrumentation, machine learning and cancer.
In Part II, the authors present key applications of various laser spectroscopic methods in cancer diagnosis. They have provided
recent progress in cancer diagnostics obtained by combining laser spectroscopy and machine learning for the analysis of the spectra acquired from biomedical tissues and biofluids.
In Part III, the authors present chapters that discuss key developments in the applications of various laser imaging techniques for cancer detection.
This is one of the few books that addresses cancer detection and diagnosis using laser spectroscopic and imaging tools with an eye on providing the reader the scientific tools, including machine learning ones.
Contents
Fundamentals
Cancer Biology and the Optical Assessment of Human Tumors (Michael J Morin)
Light Interaction with Atoms and Molecules (S Burçin Bayram, A Marjatta Lyyra and Noureddine Melikechi)
Biomedical Optics in a Nutshell (Caroline Boudoux)
Fundamentals of Optical Instrumentation for Spectroscopic and Imaging Applications (Sabrina Messaoud Aberkane, El-Hachemi Amara and Noureddine Melikechi)
Cancer Diagnosis Using Optical Methods Fundamentals of Classification with Machine Learning (David D Pokrajac)
Optical Spectroscopy:
Exogenous Fluorescence Polarization Imaging for Cancer Detection (Androniki Mitrou and Anna N Yaroslavsky)
Laser-Ablation Spectroscopy for Imaging of Tumor Markers and Nanoparticle Labels (Pavel Porízka, Pavlína Modlitbová, Noureddine Melikechi and Jozef Kaiser)
Application of ATR-FTIR Spectroscopy to the Study of Blood Sera of Patients with Breast Cancer (Vera Sitnikova, Tatiana Nosenko and Mayya Uspenskaya)
Diagnosis and Staging of Cancers Using Laser-Induced Breakdown Spectroscopy and Machine Learning (Xue Chen, Xiaohui Li and Noureddine Melikechi)
Raman Spectroscopy and Machine Learning for Diagnosis and Monitoring of Cancer (Michael Greenop, Carlos A Meza Ramirez and Ihtesham Ur Rehman)
Optical Imaging
Application of Fluorescence Lifetime Imaging in Cancer Diagnosis (Lixin Liu, Ping Xue and Junle Qu)
The Role of Machine Learning and Time-Resolved Autofluorescence Imaging for Intraoperative Cancer Margin Delineation (Jakob Unger, Mark Marsden, Takanori Fukazawa and Laura Marcu)
Laser Induced Breakdown Imaging of Biomedical Samples: A Short Review and Perspectives (Vincent Motto-Ros, Lucie Sancey, Vincent Bonneterre and Benoit Busser)
Raman Imaging, Deep Learning, and Applications to Cancer Detection (Daniel Greenfield, Saara Luna, Fotis Iliopoulos, Maria Alice Maciel Tabosa and Conor L Evans)
Skin Cancer Detection Using Optical Coherence Tomography (Brandon Lukas, Julia Roma May, Maria Tsoukas and Kamran Avanaki)
White Light Interference Phase Microscopy with Machine Learning Model for the Study of Biological Cells and Tissues.
(Dalip Singh Mehta)
Readership: Graduate students and researchers in cancer screening and diagnostics, laser spectroscopy, laser imaging, machine learning, biophotonics and biomedical sciences.
Key Features
This is one of the few books that addresses cancer detection and diagnosis using laser spectroscopic tools.
Provides specific tools to better understand the novelty that laser spectroscopy and imaging can provide.
Provides fundamentals first and then key developments made by some of the leading experts.
